In short: Yes, Vyvanse is available in South Africa. It is a Schedule 6 stimulant costing about R1,113–R1,391 for 30 capsules at retail; the generic Vyfocis costs about R780–R978.
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Vyvanse contains lisdexamfetamine, a “prodrug” that the body converts into dexamfetamine. Because it must be converted, it starts more smoothly and lasts up to 13–14 hours.
Vyvanse price in South Africa
| Strength | Vyvanse (30 caps) | Vyfocis generic (30 caps) |
|---|---|---|
| 30mg | R1,113 | R780 |
| 50mg | R1,255 | R884 |
| 70mg | R1,391 | R978 |
Retail prices from Dis-Chem as reported in May 2026; may vary by branch.
How Vyvanse works
After absorption, lisdexamfetamine is converted to dexamfetamine, which increases dopamine and noradrenaline activity. The gradual conversion means a smoother onset and offset than many stimulants.
Common side effects
- Decreased appetite
- Insomnia
- Dry mouth
- Irritability or anxiety
- Raised heart rate and blood pressure
How to get Vyvanse
Lisdexamfetamine is Schedule 6 and is prescribed by specialists. Medical aid cover depends on your plan and formulary — see our comparison.
Back to the ADHD medication guide.
Sources & further reading
- Vyvanse vs Vyfocis prices, Schooling Assessment (May 2026)
- Medicine Price Registry SEP data via medicineprices.org.za
- NHS — Medication for ADHD
- NICE NG87 — ADHD diagnosis and management
- SAHPRA — package inserts and medicine information
Last checked: 31 October 2026. If you spot something out of date, tell us.